Cialis

A protein "lock" the AIDS virus in human cells

American biologists discovered a protein that prevents new particles of human immunodeficiency virus (HIV) to withdraw from the infected cells, thus preventing virus reproduction.
The study, published in the journal Nature Medicine, believe their discovery will help to create new ways to fight HIV.
The human immunodeficiency virus that causes AIDS and other viruses, is the intracellular parasites and can not reproduce without the participation of different ways of living cell.Virus "cheat" system cells, forcing them to make viral proteins instead of their own.
Infected cells works as a kind of factory for production of viral particles - virionov that at the final stage of development must reach out through the membrane infected cells.
Scientists had previously been known that most human cells contain a factor that regulates the output of viral particles, but still a factor that has not been identified.
Biologists from the Emory University Medical School (Georgia), Vanderbilt University and the Mayo Clinic have found that HIV particle "locks" in the cell protein CAML (calcium-modulating cyclophilin ligand).
This protein works in the latter stages of the life cycle of the virus, keeping viriony in the membrane of cells. However, HIV and developed a means of defense against CAML - viral protein Vpu. When Vpu is absent, the virus particles can not be separated from the membrane.
When researchers in the laboratory "removed" from the human cell protein CAML, they found that Vpu was no longer required to exit the virus particles from the cell. When the researchers introduced CAML in cells, which under normal circumstances do not prevent the entry of HIV particles, viriony stayed on the surface of cells.
"This study is important because experience shows that CAML - is innate defense mechanism against HIV", - said one of the authors, Professor Paul Spirmen (Paul Spearman) from Emory University.